Deep Brain Stimulation

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SPEECH DEEP-BRAIN STIMULATION History SLIDE 1: Deep Brain Stimulation began with the treatment of Parkinson’s. The practice evolved from the process of burning areas of the brain where tremors from the disease were occurring. Instead of destroying the brain tissue, deep-brain stimulation sends electrodes to these areas which emit low-voltage pulses of electricity 24 hours a day. The electrical pulses were found to block the disruptive neurones caused in Parkinson’s disease. These pulses slow down the activity in the targeted areas of the brain that are overactive in the case of Parkinson’s. SLIDE 2: Electrode stimulation was first observed in monkeys in the UK who developed Parkinson’s. They showed over-activity in the sub thalamic nucleus which controls our action selections. Abrasions to the brain in this area were found to permanently reverse the effect of Parkinson’s disease in these tested monkeys. However, abrasions to the brain were found to result in damaging side effects and some brain structure was permanently destroyed. UK scientists then trialled sending electric pulses to the sub thalamic nucleus of the monkeys. The nucleus returned to a normal level of activity and reduced the tremors from Parkinson’s, without the irreversible side effects of abrasion. SLIDE 3: As early as 1987, three human patients were implanted with electrodes on both sides of their brain. This became the standard approach for treatment of Parkinson’s. Deep Brain Stimulation was given approval from the U.S. Food and Drug Administration in 2001. Since its early development, treatment of PD by DBS is now used world-wide, more than 50 000 patients with movement disorders have been successfully treated with DBS. Mechanics SLIDE 4: The human brain is one of the most complex things in the Universe. Although DBS has a long experimental history, expert medical scientists are
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