Welcome

Anti Essays offers essay examples to help students with their essay writing.

Sign Up

Aminoglycosides Essay

Open Document

Below is an essay on "Aminoglycosides" from Anti Essays, your source for research papers, essays, and term paper examples.

Aminoglycosides
Origin
  * Streptomycin sulfate which is the first aminoglycoside available for clinical use derived from the bacterium Streptomyces griseus in 1944.
Actions
  * Inhibition of bacterial protein synthesis; actericidal effect

Indications
  * Aminoglycosides are for serious infections, and currently used to treat pseudomonas aeruginosa infection include gentamicin, tobramycin, and amikacin.
  * The aminoglycoside antibiotics are used against gram-negative bacteria such as E. coli, proteus spp., and pseudomonas spp. Som gram-positive cocci are resistant to aminoglycosides, so penicillins or cephalosporins may be used. However, aminoglycosides are not effective in treating MRSA.
  * They are almost exclusively used to treat gram negative infections but are also used in lower doses in addition to beta lactams (ie. nafcillin) to provide a synergistic effect.
  * A common place for this is in the treatment of endocarditis. Clinical application: to treat bacteremia, endocarditis, health-care and nosocomial pneumonias, intra-abdominal infections, and others.
  * In combination with gentamicin or streptomycin, penicillin G and ampicillin facilitate the intracellular uptake of the aminoglycoside, which causes the subsequent bactericidal effect against the enterococci.
  * Amikacin sulfate (Amikin): effective against gram-negative bacteria, including those resistant to other aminoglycosides. Used for respiratory tract, bone joint, skin, and soft-tissue infections.
  * Gentamicin sulfate (Ganamycin): To treat serious infections caused by gram-negative organisms (e.g., Pseudomonas aeruginosa, Proteus); to trat pelvic inflammatory disease; effective against methicillin-resistant Staphylococcus aureus infections.
  * Kanamycin sulfate (Kantrex): used orally for hepatic coma. Effective against gram-negative bacteria with the exception of Pseudomonas aeruginosa.
  * Neomycin sulfate Myciguent (Neo-Fradin): decreases bacteria in the...

Show More


Citations

MLA Citation

"Aminoglycosides". Anti Essays. 26 Sep. 2017

<http://www.antiessays.com/free-essays/Aminoglycosides-603074.html>

APA Citation

Aminoglycosides. Anti Essays. Retrieved September 26, 2017, from the World Wide Web: http://www.antiessays.com/free-essays/Aminoglycosides-603074.html